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An- other macrophage-based cell therapy, which is under clinical investigation for the treatment of congestive heart failure and critical limb ischemia, is Ixmyelocel-T, a mixture of autologous macrophages and mesenchymal stem cells (MSCs) derived from a patient's bone mar- row mononuclear cells and expanded in culture over 14 days [52-54].
Thus, in order for macrophage-based cell therapies to be clini- cally viable, it will be critical to understand and control the time- and
Thus, before macrophage-based cell therapies can be translated into clinical application, it will be necessary to devise strategies that en- sure their functional stability in vivo or at least be able to predict chang- es in phenotype that may occur after administration.
Szoka, Macrophage-based cell therapies: the long and winding road, J.
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